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. 2019 Sep 12;10:4149. doi: 10.1038/s41467-019-11923-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Effects of cyclic tensile strain (CTS) on mesenchymal stem cell (MSC) behavior. a Schematic summarizing the responses of MSCs to low and high intensity CTS, and how these pathways depend on ion channel activity and SUN domain-containing protein 2 (SUN2). b Cartoon summarizing strain-induced changes to proteins in the linker of nucleoskeleton and cytoskeleton (LINC) complex and nuclear envelope (NE). ONM outer nuclear membrane; INM inner nuclear membrane