Fig. 6.

Mitochondrial and glycolytic flux in MNs derived from FUS–ALS patients and isogenic controls. a Lactate oxidation in patient (R521H or P525L) and isogenic control (R521R or P525P) motor neurons. b Glucose uptake in patient and isogenic control motor neurons. c Glycolytic flux in patient and isogenic control motor neurons. d Glucose oxidation in patient and isogenic control motor neurons. e Glutamine oxidation in patient and isogenic control motor neurons. f Fatty acid oxidation in patient and isogenic control motor neurons. The data represent mean ± s.e.m. from at least three independent experiments, with individual data points shown. Statistical analyses were performed by one-way ANOVA with post hoc two-tailed t tests between cell lines (p > 0.05). Dark grey bars indicate FUS-patient cell lines. Light grey bars indicate isogenic controls from these patients. Source data are provided as a source data file. 2DG 2-deoxy-glucose