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Summary of the metabolic pathways regulated by HIF in innate immune cell subpopulations during sepsis.
| Cell type | Early metabolic response | Late metabolic response |
|---|---|---|
| Macrophage | Activated HIF-la: ↑Giycolysis ↑Nitric oxide production ↑Pentose phosphate pathway ↓Oxidative phosphorylation Suppressed HIF-2a: ↓Arginase activity |
Suppressed HIF-la: ↑Fatty acid oxidation |
| Dendritic cell | Unknown | Activated HIF-la: ↑Glycolysis |
| Neutrophil | Activated HIF-la: ↑Glycolcysis |
Unknown |
