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Schematic displaying the role of neurotransmitter transporters in the neural synapse where they control the levels of released neurotransmitters through vesicle exocytosis. The transport is coupled to sodium and chloride gradients. Inset shows the X-ray structure of the dDAT comprising 12 TM helices and bound to dopamine (PDB ID: 4XP1). Chemical structures of neurotransmitters transported through the SLC6 family are depicted.
