Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 6;6:80. doi: 10.3389/fmolb.2019.00080

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Joseph, Pidathala, Mallela and Penmatsa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) Primary binding site in neurotransmitter transporters are subdivided into subsites A (yellow), B (magenta) and C (green). The surface of the bound drug molecule is displayed in gray. Residues involved in the ion binding sites are compared within dDAT (light blue) bound to reboxetine, represented by gray sphere (PDB ID: 4XNX) and LeuT (cyan) (PDB ID: 3F3A). The first residue in description represents dDAT followed by its equivalent in LeuT. (B) Differences in binding pockets of hSERT (magenta) bound to S-citalopram (orange) (PDB ID: 5I73) overlapped with dDAT bound to reboxetine (yellow) (PDB ID: 4XNX) and hNET homology model (cyan). The first residue in description represents hSERT followed by its equivalent in hNET. Asterisk represents five hSERT like substitutions in hNET that increase the affinity of hNET toward S-citalopram (Andersen et al., 2011).