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. 2019 Sep 6;6:80. doi: 10.3389/fmolb.2019.00080

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Copyright © 2019 Joseph, Pidathala, Mallela and Penmatsa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A,B) Extracellular and Cytosolic gating of the substrate in hSERT (PDB ID: 6DZV, 6DZZ) and LeuT (PDB ID: 3TT1, 3TT3) respectively. O_o state of the structure is represented in cyan whilst I_o state in magenta. Structures display the difference in the conformation as a consequence of TM1b, TM6a closing on the top and TM1a open to release neurotransmitter into the intracellular milieu. Intracellular network of H-bonds and hydrophobic interactions represented in the bottom panel for each molecule.