Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 6;6:80. doi: 10.3389/fmolb.2019.00080

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Joseph, Pidathala, Mallela and Penmatsa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) Cholesterol interactions observed in the NSS structures hSERT and dDAT. Cholesterol sites 1 and 2 are observed in dDAT (PDB ID: 4XP1) in the inner leaflet while site 3 is observed at TM12 region in hSERT structure (PDB ID: 5I73). (B) Site 1 is anchored in the junction between TM1, 7, and 5 and the figure displays similarities in the binding sites of both dDAT and hSERT. (C) Movement of the TM1a in hSERT structure is facilitated by absence of cholesterol. The cholesteryl hemisuccinate (CHS) was observed in the O_occ structure of hSERT (PDB ID: 6DZV).