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. 2019 Sep 6;10:2116. doi: 10.3389/fimmu.2019.02116

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Copyright © 2019 Arulraj, Binder, Robert and Meyer-Hermann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Delayed initialization of GC reaction (N = 1) with antibody feedback from early GCs (N = 300). (A) Fraction of FDC antigen bound to soluble antibodies. (B) Concentration of free antigen. (C) GC volume as number of GC B cells. (D) Number of all plasma cells produced in the delayed GC reaction. (E) Mean affinity of all plasma cells generated in the delayed GC reaction. (F) Immune power (IP) (defined in Equation 4) of the delayed GC reaction.