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. 2019 Jun 11;12(5):534–544. doi: 10.1111/cts.12649

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© 2019 Genentech. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Observed (open circle) and predicted concentration‐time profiles of DNIB0600A at 2.4 mg/kg [median (), 2.5th to 97.5th percentile (blue shaded area)] in humans. (a) Total antibody analyte, (b) conjugate measured as antibody‐conjugated MMAE (ac‐MMAE). Concentration‐time profiles of total antibody or ac‐MMAE were scaled from cynomolgus monkey using species‐invariant time method approach with exponent of 1.0 and 1.0 for clearance and volume, respectively.

Inline graphic — Observed (open circle) and predicted concentration‐time profiles of DNIB0600A at 2.4 mg/kg [median (), 2.5th to 97.5th percentile (blue shaded area)] in humans. (a) Total antibody analyte, (b) conjugate measured as antibody‐conjugated MMAE (ac‐MMAE). Concentration‐time profiles of total antibody or ac‐MMAE were scaled from cynomolgus monkey using species‐invariant time method approach with exponent of 1.0 and 1.0 for clearance and volume, respectively.