TABLE 3.

Associations of biomarkers with trajectories of global cognitive performance (N = 191).

Biomarker predictor	Association with cognitive slope			Association with cognitive level
	Beta	95% Confidence interval	p-value	Beta	95% Confidence interval	p-value
IL-6	−0.002	(−0.01, 0.01)	0.689	0.17	(−0.46, 0.80)	0.60
TNF a-R-1	−0.012	(−0.02, −0.0002)	0.046	0.80	(−0.07, 1.67)	0.07
CD14	−0.003	(−0.02, 0.01)	0.668	0.20	(−0.71, 1.11)	0.67
CD25	−0.006	(−0.02, 0.01)	0.391	0.43	(−0.47, 1.33)	0.35
CD163	−0.009	(−0.02, 0.00)	0.134	0.60	(−0.16, 1.36)	0.12

Beta coefficients for the cognitive slope represent the mean difference in rate of cognitive change per log-transformed unit difference in biomarker levels. Beta coefficients for the cognitive level refer to the mean difference in baseline level of cognitive performance per log-transformed unit difference in biomarker levels. To facilitate comparison of coefficients across tests, cognitive tests were z-standardized to have a mean of 0 and variance of 1 prior to regression. A different model was estimated for each biomarker. Models are adjusted for age, sex, years of education, and vascular risk factors.