Figure 5.

PAR2 deficiency induces glycogenesis and ascorbate production in livers of HFD-fed mice. (A–B) Plasma and liver glycolysis and glycogenesis metabolites in WT vs PAR2-KO mice fed HFD for 16 weeks were quantified by NMR-metabolomic methods. (C) Glycolysis and glycogenesis pathways and regulation in the livers of PAR2-deficient mice. Data represent mean ± SEM from 6 to 9 mice per metabolite analyzed; unpaired 2-tailed T-tests were performed, *P < 0.05, **P < 0.01, ***P < 0.001.