Table 4.
Predictors of central apneas at daytime.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| OR | CI | P-value | OR | CI | P-value | |
| In the whole population | ||||||
| Age | 1.03 | 1.02–1.05 | <0.0001 | 1.04 | 1.01–1.08 | 0.020 |
| Male gender | 2.59 | 1.81–3.69 | <0.0001 | 5.19 | 2.42–11.14 | <0.0001 |
| NYHA class | 1.51 | 1.23–1.85 | <0.0001 | - | - | - |
| ICM | 1.72 | 1.23–2.41 | 0.002 | - | - | - |
| Systemic hypertension | 1.41 | 1.02–1.95 | 0.039 | - | - | - |
| Diabetes mellitus | 1.39 | 1.01–1.93 | 0.048 | - | - | - |
| Creatinine | 1.70 | 1.18–2.46 | 0.004 | - | - | - |
| eGFR | 0.99 | 0.98–0.99 | 0.001 | - | - | - |
| LVEF | 0.98 | 0.97–0.99 | <0.0001 | - | - | - |
| LVMI | 1.01 | 1.00–1.01 | 0.004 | - | - | - |
| LA volume | 1.04 | 1.02–1.06 | <0.0001 | 1.04 | 1.01–1.08 | 0.030 |
| Diastolic dysfunction II-III | 3.40 | 2.25–5.14 | <0.0001 | - | - | - |
| Moderate-severe MR | 1.71 | 1.01–2.89 | 0.044 | - | - | - |
| sPAP | 1.02 | 1.00–1.04 | 0.033 | - | - | - |
| In the HFrEF population | ||||||
| Age | 1.05 | 1.04–1.07 | <0.0001 | 1.09 | 1.03–1.16 | 0.040 |
| Male gender | 2.34 | 1.45–3.79 | 0.001 | - | - | - |
| BMI | 1.05 | 1.00–1.10 | 0.031 | - | - | - |
| NYHA class | 1.77 | 1.33–2.36 | <0.0001 | 2.28 | 1.08–4.38 | 0.030 |
| ICM | 2.18 | 1.42–3.36 | <0.0001 | - | - | - |
| Atrial fibrillation | 1.88 | 1.14–3.13 | 0.014 | - | - | - |
| Diabetes mellitus | 1.59 | 0.99–2.54 | 0.050 | - | - | - |
| Creatinine | 2.59 | 1.51–4.45 | 0.001 | - | - | - |
| eGFR | 0.98 | 0.97–0.99 | <0.001 | - | - | - |
| C-reactive protein | 1.21 | 1.02–1.43 | 0.025 | - | - | - |
| LVEF | 0.96 | 0.93–0.99 | 0.014 | - | - | - |
| LA volume | 1.06 | 1.03–1.09 | <0.001 | - | - | - |
| Diastolic dysfunction II-III | 4.39 | 2.60–7.41 | <0.001 | 4.26 | 1.16–15.69 | 0.030 |
| sPAP | 1.03 | 1.01–1.05 | 0.012 | - | - | - |
| β-blockers | 3.17 | 1.04–9.66 | 0.040 | - | - | - |
| In the HFmrEF population | ||||||
| Male gender | 2.65 | 0.99–7.07 | 0.040 | - | - | - |
| LVMI | 1.02 | 1.00–1.04 | 0.015 | - | - | - |
| sPAP | 1.06 | 1.00–1.13 | 0.044 | 1.07 | 0.99–1.15 | 0.040 |
| In the HFpEF population | ||||||
| Male gender | 3.00 | 1.51–6.09 | 0.002 | - | - | - |
BMI, body mass index; CI, confidence interval; eGFR, estimated glomerular filtration rate (with the Modification of Diet in Renal Disease-MDRD formula); Hb, hemoglobin; ICM, ischemic cardiomyopathy; LA, left atrium; LVEF, left ventricular ejection fraction; LVMI, left ventricular mass index; MR, mitral regurgitation; NYHA, New York Heart Association; OR, odds ratio; sPAP, systolic pulmonary artery pressure; TAPSE, tricuspid annular plane systolic excursion.