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. 2019 Sep 6;10:2101. doi: 10.3389/fimmu.2019.02101

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Copyright © 2019 Gunderstofte, Iversen, Peri, Thielke, Balachandran, Holm and Olagnier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nrf2 alters the basal level of ISGs in murine macrophages. Comparison of antiviral gene expression profile by RNA-sequencing (RNAseq) analysis of wild-type (WT) and Nrf2-mutated (AY/AY) bone marrow-derived macrophages (BMMs). Differentially expressed pathways and genes that satisfied p-value <0.001 and fold change cutoff >1 or < -1 were selected. The data are from one experiment performed in triplicate. (A) rlog-transformed gene counts and a listing of representative gene ontologies and KEGG pathways associated with these genes is represented in a heatmap. (B) Representation of RNA-reads for different interferon-driven and Nrf2-driven genes from RNAseq. Graph displays boxplots with boxes indicating mean, SEM as well as min and max values. (C) Cloud analysis of differentially expressed genes from Nrf2 AY/AY BMMs related to both Nrf2 and IFN-associated pathways is represented. The experiment is a re-analysis of the work of Otsuki et al. (33) (https://www.ncbi.nlm.nih.gov/pubmed/26677805).