Table 6.
Outcomes of the ENDOCRINE DISRUPTOME prediction tool concerning the potential binding of investigated COs to the human nuclear receptors: androgen receptor (AR), estrogen receptors α (ERα) and β (ERβ), glucocorticoid receptor (GR), liver X receptors α (LXRα), and β (LRXβ), peroxisome proliferator-activated receptors α (PPRAα), β/δ (PPRAβ), and γ (PPRAγ), retinoid X receptor α (RXRα) and thyroid receptors α (TRα) and β (TRβ), an - antagonistic effect.
| Acetylation pattern | AR | AR an | ERα | ERα an | ERβ | ERβ an | GR | GR an | LXRα | LXRβ | PPARα | PPARβ | PPARγ | RXR α | TRα | TRβ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | ||||||||||||||||
| AA | ||||||||||||||||
| AAA | ||||||||||||||||
| DA | ||||||||||||||||
| ADA | ||||||||||||||||
| DADA | ||||||||||||||||
| AADD | ||||||||||||||||
| DAAD | ||||||||||||||||
| DDAA | ||||||||||||||||
| ADDA | ||||||||||||||||
| DDA | ||||||||||||||||
| ADAD | ||||||||||||||||
| D | ||||||||||||||||
| DD | ||||||||||||||||
| DDD | ||||||||||||||||
| DDDD |
Results are color coded taking into account the values of the sensitivity parameter. Class “yellow” corresponds to 0.50<SE<0.75 and indicates compounds with moderate probability of binding, and class “green” corresponds to SE>0.75 and illustrates compounds with low probability of binding to the nuclear receptors.