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. 2019 Sep 12;5(12):1774–1778. doi: 10.1001/jamaoncol.2019.2785

Figure. Association Between pATB Therapy and Survival and Response to ICIs.

Figure.

A, Kaplan-Meier curves illustrating the association of prior broad-spectrum antibiotic (pATB) therapy administered up to 30 days prior to immunotherapy with adverse survival in the study population (n = 196). B, The Figure shows the association between pATB and the best radiologic response to immune checkpoint inhibitors (ICIs) according to RECIST v 1.1 criteria. In 26 patients who received pATB therapy, 2 (8%) had a partial response (PR) to ICIs, 21 [81%] had progressive disease (PD), and 3 [11%] had stable disease (SD). In 151 patients who did not receive pATB therapy, 2 [1%] had a complete response to ICIs, 63 [42%] had PR, 20 [13%] had SD, and 66 [44%] had PD.