Table 5.
Associations of Pre- and Early Pregnancy Onset Depression and Early Pregnancy Antidepressant Treatment with Gestational Weight Gain Rate Starting at Depression Screening or Diagnosis (lbs/Week)
| N | Mean differencea (95% CI) | N | RRa (95% CI) for GWG rate below the IOM recommendations | N | RRa (95% CI) for GWG rate above the IOM recommendations | |
|---|---|---|---|---|---|---|
| No pre- or early pregnancy depressive symptoms | 72,567 | Reference | 16,970 | Reference | 39,908 | Reference |
| Prepregnancy onset depression treated with antidepressants in early pregnancy | 2142 | −0.04 (−0.10 to 0.02) | 532 | 1.34 (1.04 to 1.72) | 1256 | 1.10 (0.99 to 1.22) |
| Prepregnancy onset depression not treated with antidepressants in early pregnancy | 5554 | 0.01 (0.00 to 0.02) | 1348 | 1.09 (1.05 to 1.13) | 3195 | 1.02 (1.00 to 1.04) |
| Early pregnancy onset depression treated with antidepressants | 287 | −0.03 (−0.12 to 0.05) | 77 | 1.44 (1.07 to 1.93) | 164 | 1.12 (0.98 to 1.27) |
| Early pregnancy onset depression not treated with antidepressants | 7050 | 0.05 (0.02 to 0.08) | 1639 | 1.02 (0.96 to 1.09) | 4012 | 1.05 (1.01 to 1.08) |
a
Model is adjusted for maternal age, race/ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, Asian/Pacific Islander, Native American/multiracial, other/unknown), nulliparity (Y/N), Medicaid (Y/N), smoking in first 20 weeks of pregnancy (Y/N), alcohol use in first 20 weeks of pregnancy (Y/N), and severity of early pregnancy depressive symptoms (mild, moderate, severe).