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. 2019 Sep 13;38:403. doi: 10.1186/s13046-019-1409-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Metabolic reprogramming of T cell subsets in tumor microenvironment. Tumor mainly use glycolysis to produce energy. Glucose competition, amino acid competition, and lactic acid secretion in the tumor microenvironment influence the subsets of T cells. Tregs mainly produce energy by oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO). Similar to Treg, memory T cells maintain basic functions by increasing FAO. However, activated Teffs primarily depend on glycolysis and fatty acid synthesis