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. 2019 Sep 13;16:179. doi: 10.1186/s12974-019-1574-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Correlations of memory B cell proportions with disability in IFN-β treated MS patients. a, b Correlation between the percentage of memory B cells and EDSS scores in the NEDA (a) and EDA (b) groups of IFN-β-treated MS patients. c, d Correlation between the percentage of class-switched memory B cells and EDSS scores in the NEDA (c) and EDA (d) groups of IFN-β-treated MS patients. Correlations were calculated using Spearman’s rank correlation coefficient. CS⁺ class-switched, EDA evidence of disease activity, IFN-β interferon-β, MS multiple sclerosis, NEDA no-evidence of disease activity