Table 2.
Comparison of the percentages of γδ T cell subsets between untreated MS patients, IFN-β-treated MS patients, and healthy controls
| Untreated MS (n = 35) | MS w/ IFN-β (n = 21) | HCs (n = 44) | p value (K-W test) | padj value | |||
|---|---|---|---|---|---|---|---|
| Untreated MS vs. HCs | MS w/ IFN-β vs. HCs | Untreated MS vs. MS w/ IFN-β | |||||
| Vδ1+ | 29.0 (14.0–53.9) | 29.6 (13.7–48.3) | 18.4 (11.6–34.2) | NS | – | – | – |
| Vδ1+Vγ9+ | 3.91 (1.26–10.2) | 3.00 (1.60–5.17) | 2.15 (1.12–4.71) | NS | – | – | – |
| Vδ1+Vγ9– | 24.3 (10.2–40.8) | 23.5 (10.0–38.3) | 15.5 (8.47–31.5) | NS | – | – | – |
| Vδ2+ | 32.9 (13.3–52.3) | 21.2 (5.07–33.4) | 54.9 (31.7–65.9) | < 0.001 | 0.047 | < 0.001 | 0.017 |
| Vδ2+Vγ9+ | 32.7 (12.9–52.2) | 21.1 (4.70–32.1) | 54.3 (31.1–65.7) | < 0.001 | 0.043 | < 0.001 | 0.016 |
| Vδ2+Vγ9– | 0.16 (0.07–0.46) | 0.16 (0.00–0.44) | 0.08 (0.03–0.29) | NS | – | – | – |
| Vδ1−Vδ2− | 22.8 (15.5–39.5) | 35.6 (27.1–58.2) | 22.8 (17.1–30.3) | 0.001 | NS | < 0.001 | 0.002 |
| Vδ1−Vδ2−Vγ9+ | 1.23 (0.36–2.91) | 1.10 (0.33–2.53) | 2.42 (1.25–3.83) | 0.010 | NS | 0.009 | NS |
| Vδ1−Vδ2−Vγ9− | 22.0 (14.7–36.1) | 33.1 (24.5–55.3) | 18.1 (10.7–26.4) | < 0.001 | NS (0.073) | < 0.001 | < 0.001 |
Values are the median (IQR). Percentages of each population in total γδ T cells are shown
p values (K-W test) were obtained by Kruskal-Wallis analyses, and if they were statistically significant, then padj values were calculated using multivariate linear regression analyses adjusted for age and sex
HCs healthy controls, IFN-β interferon-β, IQR interquartile ranges, K-W Kruskal-Wallis, MS multiple sclerosis, NS not significant, w/ with