Table 4.
Comparison of the percentages of B cell subsets between untreated MS patients, IFN-β-treated MS patients, and healthy controls
| Untreated MS (n = 35) | MS w/ IFN-β (n = 21) | HCs (n = 44) | p value (K-W test) | padj value | |||
|---|---|---|---|---|---|---|---|
| Untreated MS vs. HCs | MS w/ IFN-β vs. HCs | Untreated MS vs. MS w/ IFN-β | |||||
| Naïve (CD27−IgD+) | 46.3 (27.9–56.8) | 48.9 (37.7–58.9) | 51.8 (41.4–60.6) | NS | – | – | – |
| Memory (CD27+) | 14.8 (10.3–27.0) | 9.84 (6.89–15.2) | 22.7 (16.9–29.9) | < 0.001 | NS | < 0.001 | 0.009 |
| CS+ memory (CD27+IgD−) | 12.4 (9.27–24.8) | 7.97 (6.10–14.0) | 18.8 (14.4–25.2) | < 0.001 | NS | < 0.001 | 0.006 |
| CS− memory (CD27+IgD+) | 1.91 (0.83–2.68) | 0.99 (0.85–1.67) | 3.49 (2.49–4.67) | < 0.001 | NS (0.058) | < 0.001 | NS |
| Plasmablasts (CD38highCD20−) | 0.31 (0.14–0.65) | 0.32 (0.25–0.53) | 0.37 (0.24–0.67) | NS | – | – | – |
| Transitional (CD24highCD38high) | 3.16 (1.75–5.93) | 5.90 (1.92–7.66) | 3.14 (2.32–4.45) | NS | – | – | – |
Values are the median (IQR). Percentages of each population in total B cells are shown
p values (K-W test) were obtained by Kruskal-Wallis analyses, and if they were statistically significant, then padj values were calculated using multivariate linear regression analyses adjusted for age and sex
CS+ class-switched, CS− non-class-switched, HCs healthy controls, IFN-β interferon-β, IQR interquartile ranges, K-W Kruskal-Wallis, MS multiple sclerosis, NS not significant, w/ with