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. 2019 Sep 13;17:122. doi: 10.1186/s12964-019-0428-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Syk inhibitors differentially affect Syk tyrosine phosphorylation. Human washed platelets (WP) were treated as mentioned in Fig. 3. Samples were taken after 15, 60 and 120 s. a Representative blots of Syk phosphorylation on Y525/526 and Y352 and the corresponding quantification shown as ratio compared to the total Syk protein represented in b and c respectively. d Representative blots of Syk downstream effectors PLCγ2 Y759 and Akt S473 and the corresponding quantification e and f shown as ratio compared to the total PLCγ2 and Akt respectively. Data are means ± S.D. from 3 independent experiments with platelets from 3 healthy donors; ns: not significant, ***p < 0.001, ****p < 0.0001