Figure 3.

Effects of hGIP(1-42), hGIP(1-30) and mGIP(1-30) on glucose tolerance in mice. Blood glucose concentrations (A) were measured before and 15, 30 and 60 minutes after intraperitoneal injection of glucose alone (18 mmol/kg bw), or in combination with test peptides (each at 50 nmol/kg bw) in fasted mice. (B) Blood glucose area under the curve (AUC) values for 0 to 60 minutes post injection.

Abbreviations: AUC indicates area under the curve; hGIP, human glucose-dependent insulinotropic polypeptide; mGIP, mouse glucose-dependent insulinotropic polypeptide.

Values represent means ± standard error of mean (n = 5-6). *P < 0.05, **P < 0.01 compared with glucose alone.