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. 2019 Jul 21;16(8):1057–1071. doi: 10.7150/ijms.35611

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The differentially expressed miRNAs and mRNAs in HFLS and HFLS-OA displayed in heatmaps were indicated in left and right panels, respectively. Putative targets of dysregulated miRNAs were predicted from the miRmap database, selecting those with miRmap scores of ≥ 99.0 indicating high repression strength. The putative targets were matched to differentially expressed mRNAs in HFLS, and the Venn diagram was displayed in the middle panel. A total of 11 up-regulated genes and 3 down-regulated genes with potential miRNA regulations were identified.