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. 2019 Jul 21;16(8):1057–1071. doi: 10.7150/ijms.35611

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The expression patterns of 14 target genes, including (A) 11 up-regulated and (B) 3 down-regulated genes were analyzed in one of the OA synovial tissue datasets extracted from GEO database (GSE55235). The significantly up-regulated expressions in SKAP2, KIF1B, TFAP2A, CACNA2D1 and AP1S2, and significantly down-regulated expressions in PHF21A and LPP in OA knee synovial tissues were in similar expression patterns to our HFLS-OA data. * indicated p < 0.05, ** indicated p < 0.01, *** indicated p < 0.001, and n.s. indicated no statistical significance between normal and OA groups.