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Molecular mechanisms of KLF15 in podocyte injury. KLF15 mediates RA and GCs-induced restoration of podocyte differentiation markers (Nephrin, Synaptopodin, and Podocin) under podocyte stress. Pathways activated by KLF15 include stabilization of the actin cytoskeleton, podocyte differentiation, and focal adhesion. The activity of KLF15 is partly mediated by WT1.
