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. 2019 Jul 20;15(9):1882–1891. doi: 10.7150/ijbs.31999

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IL-6 induced EMT through activation of IGF-1R. Cells were treated with IL-6 (50ng/ml) in the presence of IGF-1R inhibitor AG1024 (5uM/L) (A and C) or IGF-1 neutralizing antibody (10ug/ml) (B and D) and harvested after 48 hours for western blotting of EMT markers. Activation of IL-6R and IGF-1R was measured in the presence of IGF-1 antibody (E) or when the neutralizing antibody of both IGF-1 and IL-6 were present (F). Blots were representatives of three experiments and results were quantified using Quantity One for comparisons between IL-6 group and control or between IL-6 plus an inhibitor (AG1024 or IGF-1 antibody) co-treated cells and IL-6 group. *, p<0.05. #, p>0.05 not significant.