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Inhibiting either STAT3 or IGF-1R attenuates cell migration. PC-9 cells (A) and A549 cells (B) were seeded and treated either with IL-6 alone or in the presence of both IL-6 and an STAT3 or IGF-1R inhibitor. Migration was shown as photograph and the number of migratory cells was determined using a transwell matrix penetration assay and quantified for analysis of significance. *, p<0.05. #, p>0.05 not significant.
