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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Clin Cancer Res. 2018 Jul 3;24(19):4798–4807. doi: 10.1158/1078-0432.CCR-17-3284

Figure 2.

Figure 2.

Enzymatic degradation of tumor HA increases tumor perfusion, vascular volume, and extracellular pH, while decreasing tumor hypoxia. A, Tumor HA degradation with low-dose PEGPH20 increased tumor perfusion (left plot), and vascular volume (middle plot), and reduced hypoxia (right plot) in HA-accumulating AsPC-1/HAS3. B, TME pHe increased after treatment with PEGPH20. C, A tabular list of six tumor xenografts and the relative decrease in hypoxia associated with low-dose PEGPH20 treatment.