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Berberine improves glucose absorption and metabolism in diabetic rats. (A, B) Glucose levels in diabetic rat’s periphery and CSF, n = 8–12. (C, D) The insulin levels in diabetic rat’s periphery and CSF, n = 8–12. (E, F) The glucose metabolism in the brain were measured by PET imaging and quantified by fluorescence intensity, n = 3. *P < 0.05 vs. Nor; **P < 0.01 vs. Nor; ***P < 0.001 vs. Nor; ****P < 0.0001 vs. Nor; # P < 0.05 vs. DM; ## P < 0.01 vs. DM
