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Berberine ameliorates the cholinergic signaling pathway dysfunction. (A, B) The AChE activity and ACh levels in diabetic rat’s periphery, n = 8–12. (C, D) The AChE activity and ACh levels in diabetic rat’s hippocampus, n = 8–12. (E, F) The a7nAChR expression in diabetic rat’s hippocampus was detected by Western-blot and quantified by image J, n = 3. **P < 0.01 vs. Nor; ***P < 0.001 vs. Nor; # P < 0.05 vs. DM; ## P < 0.01 vs. DM.
