FIGURE 6:

Modification of the model with the epithelial TCJs. (A) The comparison between experiments (Bosveld et al., 2016) and simulations with and without the TCJ mechanism (also see Supplemental Movie S5). The blue, red, and green lines in the experimental images indicate the directions of the cell shape polarity, the TCJ polarity, and the actual spindle orientation, respectively. Scale bar: 5 µm. (B) We randomly generated 1000 polygonal cells and computed the directions of the cell shape polarity and the TCJ polarity. The distribution of the difference between the two directions (θ_TCJ−θ_shape) is in good agreement with the experimental data (Bosveld et al., 2016). (C, D) The difference between the spindle orientation and the cell shape polarity (blue) or the TCJ polarity (red) obtained from the simulations with and without the TCJ mechanism.