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. 2019 Sep 1;30(19):2458–2468. doi: 10.1091/mbc.E19-04-0227

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© 2019 Li et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 7: — Regulating the spindle orientation via cell shape and TCJs in the top view. (A) When subjected to anisotropic stress, the rounding cell could exhibit an elliptical shape during the mitotic phase (Wyatt et al., 2015), probably leading to the inconsistency of the TCJ polarity and the cell shape polarity. The schematic shows an example that the long axis of the elliptical cell is perpendicular to the TCJ polarity. (B) The snapshots of the simulated spindles in the cells with different aspect ratios but the same force and anisotropy of the TCJs (f = 5 pN, θ = 15°). Scale bar: 5 µm. (C) The spindle orientation is plotted against the aspect ratio of the cell shape with various anisotropy of the TCJs. (D) The spindle orientation is plotted against the aspect ratio of the cell shape with various forces generated at the TCJs. (E) The critical aspect ratio λ_T as the function of the anisotropy and the pulling force at the TCJs is obtained by using Eq. 1 to fit the curves in C and D and other cases.