TABLE 1.

Optogenetic epilepsy studies.

References	Brake	Drive	Kindle	Area
Cela et al., 2019			✓	Motor	Cortex
Khoshkhoo et al., 2017		✓		Motor
Wykes et al., 2012	✓			Motor
Assaf and Schiller, 2016	✓	✓		Somatosensory
Chang et al., 2018		✓		Somatosensory
Berglind et al., 2014	✓			CA3	Hippocampus
Berglind et al., 2018	✓			CA3
Bui et al., 2018	✓			Dentate gyrus
Chen S. et al., 2018	✓			CA1 + DG
Chiang et al., 2014	✓			CA3
Krook-Magnuson et al., 2013	✓			CA1
Krook-Magnuson et al., 2015	✓	✓		Dentate gyrus
Ladas et al., 2015	✓			Dentate gyrus
Lu et al., 2016	✓			Dentate gyrus
Osawa et al., 2013		✓		CA3 + DG
Sessolo et al., 2015		✓		Temporal cortex
Shiri et al., 2015		✓		Entorhinal cortex
Tonnesen et al., 2009	✓			Hippocampus
Wang et al., 2017	✓			Subiculum
Weitz et al., 2015		✓		Hippocampus
Yekhlef et al., 2015	✓			Entorhinal cortex
Krook-Magnuson et al., 2014	✓			Lateral	Cerebellum
Kros et al., 2015	✓			LCN and MCN
Soper et al., 2016	✓			Superior colliculus	Midbrain
Paz et al., 2013		✓		Ventrobasal	Thalamus
Sorokin et al., 2017	✓	✓		Ventrobasal

Studies to date using optogenetics either to interrupt (“Brake”), promote seizures (“Drive”) or kindle (“Kindle”) (also see Figure 1). DG denotes the Dentate gyrus, CA1 Cornu Ammonis subfield 1, CA3 Cornu Ammonis subfield 3, LCN lateral cerebellar nuclei, and MCN medial cerebellar nuclei.