Table 1.
Overview of GWAS for AF.
| Year | Cases (n) | Referents (n) | Ancestry | N new loci* | Total N loci** | Authors | References |
|---|---|---|---|---|---|---|---|
| 2007 | 550 | 4,476 | European (Iceland) | 1 (4q25 (PITX2)) |
1 | Gudbjartsson et al. | (20) |
| 2009 | 2,385 | 33,752 | Mostly European ancestry, ~11% Chinese | 1 (ZFHX3) |
2 | Gudbjartsson et al. | (24) |
| 2009 | 3,413 | 37,105 | European | 0 (ZFHX3) |
2 | Benjamin et al. | (25) |
| 2010 | 1,335 | 12,844 | European | 1 (KCNN3) |
3 | Ellinor et al. | (30) |
| 2012 | 6,707 | 52,426 | European | 6 (PRRX1,CAV1,C9orf3, SYNPO2L (MYOZ1), SYNE2, HCN4) |
9 | Ellinor et al. | (28) |
| 2014 | 7,550 | 55,776 | European | 5 (NEURL, CAND2, GJA1, TBX5, CUX2) |
14 | Sinner et al. | (31) |
| 2017 | 17,931 | 115,142 | European, Asian, and African-American | 12 (METTL11B–KIFAP3, ANXA4–GMCL1, CEP68, TTN/TTN-AS1, KCNN2 KLHL3–WNT8A–FAM13B, SLC35F1–PLN, ASAH1–PCM1 SH3PXD2A, KCNJ5, SCN10A, SOX5) |
26 | Christophersen et al. | (32) |
| 2017 | 8,180 | 28,612 | Asian (Japanese) | 6 (KCND3, PPFIA4, SLC1A4–CEP68, HAND2, NEBL and SH3PXD2A) |
31 | Low et al. | (33) |
| 2017 | 672 | 3,700 | Asian (Korea) | 0 PPFIA4, HAND2 |
31 | Lee et al. | (34) |
| 2018 | 6,337 | 61,607 | European | 1 1p32 |
32 | Nielsen et al. | (35) |
| 2018 | 65,446 | ≈500,000 | Combined 84.2% European, 12.5% Japanese, 2% African American, 1.3% Brazilian and Hispanic populations | 70 | 102 | Roselli et al. | (36) |
| 2018 | 60,000 | 970,216 | European | ≈10 | ≈134 | Nielsen et al. | (37) |
The table gives an overview of GWAS for AF from the first locus reported in 2007 until 2018.
*
Number of genetic loci that have not previously been reported in relation to AF.
**
Total number of genetic loci associated with AF, summed up by previously reported loci in addition to new loci of the current year. The data from the table are illustrated in Figure 1.