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. 2019 Sep 6;10:2129. doi: 10.3389/fimmu.2019.02129

Figure 1.

Figure 1

Ibrutinib or acalabrutinib attenuate the cardiac dysfunction caused by CLP-sepsis. Mice were randomly assigned to undergo CLP or sham surgery (n = 10). One hour later, mice were treated with ibrutinib (30 mg/kg i.v.), acalabrutinib (3 mg/kg i.v.), or vehicle (5% DMSO + 30% cyclodextrin i.v.). Cardiac function was assessed 24 h after CLP surgery (n = 10 per group). (A) Illustration of the timelines of the CLP model. (B) Representative M-mode echocardiograms. (C) Ejection fraction (%). (D) Fractional shortening (%). (E) Fractional area change (%). (F) CXCL10 serum concentration (pg/ml). (G) CXCL11 serum concentration (pg/ml). (H) correlation of ejection fraction and CXCL10 serum concentration. (I) Correlation of ejection fraction and CXCL11 serum concentration. All data are expressed as mean ± SEM for n number of observations. A value of ****P < 0.0001, ***P < 0.001, **P < 0.01 was considered to be statistically significant when compared to the control by one-way ANOVA followed by a Bonferroni's post-hoc test. Correlations coefficients were determined by Pearson's correlation with P-values based on two-tailed tests.