TABLE 4.

Multivariate analyses for disease-specific survival and combined recurrence

Disease-specific survival Multivariate analysis				Combined recurrence Multivariate analysis
	P value	HR (if P < .10)	95% CI		P value	HR (if P < .10)	95% CI
Age, per 5 y	.0002	1.16	1.07–1.25	Grade combined	.0059
Grade combined	.023			Low-grade vs unspecified		0.71	0.32–1.62
Low-grade vs unspecified		1.26	0.35–4.57	High-grade vs low-grade		2.29	1.34–3.92
High-grade vs low-grade		3.05	1.02–9.09	High-grade vs unspecified		1.64	0.83–3.25
High-grade vs unspecified		2.42	1.07–5.49
Distant recurrence	<.0001	2.94	1.90–4.57
Local recurrence	.0003	2.24	1.44–3.48

Note: Age, sex, race, functional status, tumor size, histology, final margin status, histologic grade, node positivity, local recurrence, distant recurrence, other organ involvement on pathology, tumor rupture, (neo)adjuvant chemotherapy, (neo)adjuvant radiotherapy were included in the univariate. Abbreviations: CI, confidence interval; HR, hazard ratio.