S6.

Univariate and multivariate Cox regression analysis of clinicopathological parameters and risk score for overall survival in TCGA GBM cohort

Factor	Univariate analysis			Multivariate analysis
	HR (95%CI)	P		HR (95%CI)	P
KPS, Karnofsky performance status; IDH, isocitrate dehydrogenase; MGMT, O(6)-methylguanine-DNA methyltransferase; HR, hazard ratio; CI, confidence interval.
Gender	0.995 (0.691, 1.432)	0.977
Age	1.029 (1.013, 1.044)	< 0.001		1.034 (1.013, 1.055)	0.001
KPS score	0.893 (0.568, 1.405)	0.625
IDH status	0.229 (0.092, 0.568)	0.001
MGMT status	0.568 (0.368, 0.875)	0.010		0.600 (0.382, 0.941)	0.026
Expression subtypes	1.509 (1.015, 2.245)	0.042
Radiotherapy	0.467 (0.171, 1.279)	0.138
Chemotherapy	0.672 (0.396, 1.141)	0.141
Risk score	2.714 (1.924, 3.829)	< 0.001		2.046 (1.321, 3.168)	0.001