3.

Continued
Characteristics	Univariate analysis				Multivariate analysis
	Mean survival (month) (95% CI)	Log rank	P		HR (95% CI)	P
*P < 0.05 was considered statistically significant.Abbreviations: ER, estrogen receptor; Her-2, human epidermal growth factor receptor 2; HR (+), hormonal receptor (+); PR, progestrone receptor; TN, triple negative.
Histologic type		1.243	0.265
Invasive ductal carcinoma	65 (60–70)
Other	57 (57–57)
ER		7.609	0.006*
Negative	54 (45–63)				1
Positive	71 (65–76)				0.467 (0.042–5.207)	0.536
PR		2.832	0.092
Negative	58 (50–65)				1
Positive	69 (63–75)				2.170 (0.220–21.410)	0.507
Her-2		1.032	0.310
Negative	67 (61–74)
Positive	61 (53–70)
Postsurgical Ki67		5.992	0.014*
≤ 25%	71 (65–77)				1
> 25%	56 (49–64)				1.771 (0.649–4.832)	0.265
Ki67 decrease		0.566	0.452
≤ 12.5%	64 (56–71)				1
> 12.5%	68 (61–75)				0.898 (0.349–2.311)	0.824
Molecular subtype		7.766	0.051
HR(+)/Her-2(–)	70 (64–76)				1
HR(+)/Her-2(+)	70 (60–80)				0.662 (0.122–3.603)	0.633
HR(–)/Her-2(+)	54 (42–65)				2.591 (0.200–33.574)	0.466
TN	49 (33–65)				2.500 (0.172–36.273)	0.502