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. 2019 Aug;16(3):498–513. doi: 10.20892/j.issn.2095-3941.2019.0073

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Copyright 2019 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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KCTD12 downregulation promotes B16F10 cells’ proliferative and metastasis-related capacities. (A) KCTD12 knockdown via siRNA in B16F10 cells was confirmed by RT-qPCR (left panel) and Western blot (middle and right panels). (B) Proliferative capacity and (C) heterogeneous adhesion capacity (1 h) of B16F10 cells were enhanced after KCTD12 siRNA treatment. Scale bars: 200 μm. (D) Transmigration capacity and (E) invasion capacity of B16F10 were strengthened after KCTD12 siRNA treatment (72 h). Scale bars: 100 μm for D and 50 μm for E. Data are mean ± SD (n= 3 - 5); *, P < 0.05; **, P < 0.01, determined by one-tailed unpaired t-test.