Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug;16(3):498–513. doi: 10.20892/j.issn.2095-3941.2019.0073

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2019 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

PMC Copyright notice

Knockout of KCTD12 promotes the metastasis of melanoma cells in vivo, and the schematic illustration of the potential mechanism. (A) Body weight changes of the mice (n = 4 per group) intravenously injected with A375 and A375-KCTD12-KO cells (2 × 10⁶ per mouse). (B) The visceral metastasis rate of mice injected with A375 and A375-KCTD12-KO cell lines. (C) Statistical analysis of the metastatic nodes in the visceras. (D) H&E staining of the main viscera from the two groups. (E) Schematic illustration of the potential mechanism by which KCTD12 downregulation promotes melanoma metastasis.