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. 2019 Aug;16(3):542–555. doi: 10.20892/j.issn.2095-3941.2018.0407

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Copyright 2019 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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HS activates PKCa-ERK1/2-FRA-1 cascade. (A) Western blot measurement of ERK1/2, FRA-1 and PKCa phosphorylation in HS-treated CRC cells. (B) PKC activity measurement of CT-26 and SW620 cells after HS treatment for 5 days. (C) Western blot analysis of p-ERK1/2, p-FRA-1 and p-PKCa expression in control, HS-treated CT-26 and SW620 cells in the presence or absence of U0126, Gö6976 or FRA-1 siRNA. C: control, G: Gö6976, U: U0126. The quantification value was labeled above the bands. All data were from three independent experiments.