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. 2019 Aug;16(3):542–555. doi: 10.20892/j.issn.2095-3941.2018.0407

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Copyright 2019 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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The induction of ERK1/2 and Fra-1 phosphorylation by heat shock is independent of c-Met activation. (A) Western blot assay showed HGF induced c-Met and down stream ERK phosphorylation in a dose-dependent manner. (B) c-Met inhibitor PHA-665752 blocked HGF induced c-Met and ERK phosphorylation in a dose-dependent manner. (C) Western blot assay showed c-Met was not phosphorylated by heat shock, even though downstream ERK was activated. Furthermore, c-Met inhibitor PHA-665752 cannot block the ERK and Fra-1 phosphorylation induced by 45°C heat shock in CT-26 cells.