Table 1. Table 1. Reported cases of insulin degludec use during pregnancy.

Table modified from reference [7]. BMI: body mass index, kg: kilograms, g: grams, cm: centimeters, NICU: neonatal intensive care unit, NPDR: non-proliferative diabetic retinopathy, PDR: proliferative diabetic retinopathy.

	Case 1 [7]	Case 2 [7]	Case 3 [7]	Case 4 [6]	Case 5 [6]	Case 6 [8]	Case 7
Mothers
Age, years	37	26	22	34	22	31	33
Type of diabetes	1	1	1	1	1	2	1
Diabetes duration, years	10	19	13	8	16	3	17
Pre-pregnancy BMI, kg/m2	21.5	25	21.6	22.7	36.1	33.9	27
HbA1c (mmol/mol)
Pre-conception	8.5 (69)	9.4 (79)	9.2 (77)	6.3 (45)	7.7 (61)	6.6 (49)	8.9 (74)
First trimester	7.2 (55)	7.4 (57)	9.9 (85)	6.0 (42)	6.6 (49)	6.6 (49)	6.1 (43)
Second trimester	6.8 (51)	7.3 (56)	7.6 (60)	5.8 (40)	5.7 (39)	5.6 (38)	7.1 (54)
Third trimester	6.7 (50)	6.3 (45)	8.2 (66)	5.2 (33)	5.0 (31)	6.1 (43)	Not done
Micro-/macrovascular complications
Before pregnancy	NPDR	No	No	No	No	No	PDR
During pregnancy	No	No	No	No	No	No	Pre-eclampsia
Degludec treatment during pregnancy, in weeks	29	5	7	12	8	38	34
Weight gain at the end of pregnancy, kg	6	8	10	9	8	7	14
Time of delivery, weeks	29	35	37	37	37	38	34
Delivery	Caesarean	Caesarean	Caesarean	Caesarean	Induced	Caesarean	Caesarean
Newborn
Birth weight, g	1730	2900	3930	3330	3300	3280	2500
Length, cm	41	--	50	54.5	50	49	43
Congenital malformations	No	No	No	No	No	No	No
APGAR score at 1 and 5 min	7/10, 8/10	10/10, 10/10	9/10, 10/10	8/10, 9/10	9/10, 10/10	8/10, 9/10	6/10, 8/10
Neonatal hypoglycemia	No	No	No	Yes, mild	Yes, moderate	No	No
NICU admission	Yes (bilirubin increase and episodes of apnea)	No	No	Yes (respiratory distress)	Yes (bilirubin increase)	No	Yes (respiratory distress)