Plots of (a) children and (b) adults show the adjusted linear regression coefficients (β) from multivariable models, with tails indicating lower and upper confidence limits. For ease of comparison, each β estimate has been plotted as the negative of its absolute value, in which negative numbers indicate a worse patient-reported outcome. The dashed line denotes the minimally important difference from baseline. CI, confidence interval; HRqOl, health-related quality of life; PROMIS, Patient-Reported Outcomes Measurement Information System.