Fig 7. A model for the developmental coordination of cell cycle exit and chromatin accessibility.

Potential regulatory elements at complex cell cycle genes such as stg become inaccessible in a developmentally controlled manner during robust G0. This may limit their activation in response to proliferative signals. Delaying or disrupting cell cycle exit impacts the subsequent opening of chromatin at genes in the wing terminal differentiation program that are potentially controlled via transcription factors downstream of ecdysone signaling. Cpr, Cuticular protein; cycE, cyclin E; E2F, E2F transcription factor; stg, string.