Table 3.
Number and Percentage of Patients Who Experienced Severe Clinical Outcomes, by Plasma Gelsolin Quartiles
| Plasma Gelsolin Quartile(n [Column %]) | |||||||
|---|---|---|---|---|---|---|---|
| Quartile 1(≤32.1 μg/mL) | Quartile 2(32.2–38.1 μg/mL) | Quartile 3(38.2–45.7 μg/mL) | Quartile 4(≥45.8 μg/mL) | Quartiles 2–4(≥32.2 μg/mL) | P Value(Quartile 1 vs Quartiles 2–4) | ||
| Outcome | (n = 113) | (n = 114) | (n = 114) | (n = 114) | (n = 342) | ||
| Outcome severity category | |||||||
| Category 4 (death) | 10 (8.8) | 0 | 3 (2.6) | 0 | 3 (0.9) | <.0001 | |
| Category 3 (IRVS) or category 4 (death) | 28 (24.8) | 12 (10.5) | 14 (12.3) | 14 (12.3) | 40 (11.7) | .0007 | |
| Category 2 (ICU), category 3 (IRVS), or category 4 (death) | 73 (64.6) | 50 (43.9) | 46 (40.4) | 44 (38.6) | 140 (40.9) | <.0001 | |
| Discrete outcomes | |||||||
| IRVS | 24 (21.2) | 12 (10.5) | 14 (12.3) | 14 (12.3) | 40 (11.7) | .0114 | |
| Invasive respiratory support | 19 (16.8) | 11 (9.6) | 9 (7.9) | 10 (8.8) | 30 (8.8) | .0168 | |
| Vasopressor support | 16 (14.2) | 5 (4.4) | 7 (6.1) | 9 (7.9) | 21 (6.1) | .0069 | |
| ICU care | 72 (63.7) | 50 (43.9) | 46 (40.4) | 44 (38.6) | 140 (40.9) | <.0001 | |
| Bacterial pathogen detected | 29 (25.7) | 13 (11.4) | 16 (14.0) | 8 (7.0) | 37 (10.8) | .0001 | |
Abbreviations: ICU, intensive care unit; IRVS, invasive respiratory or vasopressor support.