1.
749例CHB-肝纤维化患者基线指标比较分析
Baseline demographics and biochemical characteristics of 749 CHB patients with fibrosis
| Characteristics | ETV group (n=185) | ETV+FFBJ group (n=180) | TDF group (n=131) | TDF+FFBJ group (n=135) | ADV group (n=58) | ADV+FFBJ group (n=60) | χ2/F | P |
| AFP: Alpha-fetoprotein; HBeAg + : Positive for HBeAg. For descriptive purposes, quantitative variables are presented as either the mean with standard deviation or medians and ranges, as appropriate. Categorical variables are presented as number and percentages. Comparisons across groups were performed using chi-squared test or Fisher's exact test for categorical variables. P < 0.05 was considered statistically significant. | ||||||||
| Age (year) | 40.1±11.3 | 41.1±9.4 | 41.0±9.0 | 39.2±7.9 | 41.2±9.4 | 42.9±9.4 | 1.426 | 0.216 |
| Male (%) | 131 (70.8%) | 132 (73.3%) | 85 (64.9%) | 81 (60.0%) | 42 (72.4%) | 43 (71.7%) | 8.432 | 0.134 |
| HBsAg (U/mL) | 10163.4 (73.3, 20560.4) | 13171.3(225.4, 26413.1) | 10428.1(832.2, 24560.0) | 11691.4 (369.7, 26370.1) | 10738.7 (228.7, 27660.7) | 11424.1 (120.4, 27913.5) | 7.862 | 0.164 |
| HBeAg+(%) | 90 (48.6%) | 91 (50.6%) | 70 (53.4%) | 69 (51.1%) | 26 (44.8%) | 27 (45.0%) | 2.051 | 0.842 |
| HBV DNA (lg U/mL) | 5.14 (1.92, 7.62) | 5.34 (2.04, 8.00) | 4.84 (1.17, 7.87) | 5.34 (2.33, 7.99) | 5.05 (2.32, 7.54) | 4.55 (2.09, 6.93) | 6.303 | 0.278 |
| ALT (U/L) | 122.7 (20.4, 206.6) | 143.7 (25.1, 219.0) | 123.3 (21.2, 198.2) | 132.5 (25.9, 198.8) | 120.9 (25.1, 218.4) | 128.6 (31.1, 186.4) | 9.586 | 0.088 |
| AFP (ng/mL) | 5.7 (3.0, 76.4) | 5.8 (3.8, 101.5) | 5.7 (4.2, 62.3) | 5.5 (3.6, 58.8) | 5.3 (3.2, 42.2) | 6.0 (3.6, 38.5) | 5.986 | 0.308 |
| FibroScan (Kpa) | 16.2 (7.2, 62.8) | 17.0 (7.4, 56.8) | 16.2 (7.4, 53.5) | 17.6 (8.0, 58.6) | 15.5 (7.2, 49.2) | 17.5 (7.2, 53.6) | 1.529 | 0.910 |
| Metavir | ||||||||
| F0≤5 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| F1≤7.1 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| F2≤9.5 | 30 (16.2%) | 31 (17.2%) | 23 (17.6%) | 20 (14.8%) | 9 (15.5%) | 8 (13.3%) | 7.821 | 0.993 |
| F3≤12.5 | 32 (17.3%) | 27 (15.0%) | 20 (15.3%) | 22 (16.3%) | 8 (13.8%) | 8 (13.3%) | ||
| F4.1 (12.5-20) | 62 (33.5%) | 54 (30.0%) | 46 (35.1%) | 49 (36.3%) | 22 (37.9%) | 25 (41.7%) | ||
| F4.2 (20-50) | 55 (29.7%) | 63 (35.0%) | 39 (29.8%) | 42 (31.1%) | 19 (32.8%) | 17 (28.3%) | ||
| F4.3 (> 50) | 6 (3.2%) | 5 (2.8%) | 3 (2.3%) | 2 (1.5%) | 0 | 2 (3.3%) | ||