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研究对象的人口统计学及临床基线资料
Baseline clinical characteristics of patients with and without major depression at 3 months
| Variate | No major depression (n=272) | Major depression (n=104) | Normal control (n=120) | aP | bP |
| BMI: Body mass index; NIHSS: National Institutes of Health Stroke Scale; mRS: Modified Rankin Scale; MMSE: Mini mental state examination; NLR: Neutrophil/lymphocyte ratio; PLR: Platelet-To-Lymphocyte ratio; IL 17: Interleukin 17; IL6: Interleukin 6; IQR: Interquartile range; SD: Standard deviation; PSD: Post-stroke depression. a: Major depression compared to no major depression; b: Major depression compared to normal controls. | |||||
| Demographic characteristics | 61.74±10.52 | ||||
| Age (year, Mean±SD) | 60.64±10.02 | 51 (49.04) | 60.21±10.37 | 0.348 | 0.275 |
| Female (%) | 101 (37.13) | 6.10±3.06 | 52 (43.33) | 0.035 | 0.393 |
| Educational (y), median (IQR） | 5.36±3.11 | 24.78±2.57 | 0.039 | ||
| BMI (kg/m2), median (IQR） | 24.12±2.13 | 36 (34.62) | 0.012 | ||
| Widowhood (%) | 28 (10.29) | 〈0.001 | |||
| Vascular risk factors[n (%)] | 72 (69.23) | ||||
| Hypertension | 186 (68.38) | 33 (31.73) | 0.874 | ||
| Hyperlipidaemia | 85 (31.25) | 48 (46.15) | 0.928 | ||
| Diabetes mellitus | 116 (42.62) | 34 (32.69) | 0.540 | ||
| Coronary heart disease | 79 (29.04) | 35 (33.65) | 0.490 | ||
| Atrial fibrillation | 81 (29.78) | 43 (41.35) | 0.467 | ||
| Active smokers | 101 (37.13) | 36 (34.62) | 0.452 | ||
| Alcohol consumption | 91 (33.46) | 0.832 | |||
| Tht Type of stroke etiology[n (%)] | 63 (60.57) | 0.390 | |||
| Atherothrombotic | 156 (57.35) | 15 (14.42) | |||
| Lacunar | 73 (26.84) | 7 (6.73) | |||
| Cardioembolic | 6 (2.21) | 19 (18.27) | |||
| Others | 37 (13.60) | ||||
| Leision location[n (%)] | 17 (16.35) | 0.459 | |||
| Frontal | 55 (20.22) | 13 (12.50) | |||
| Parietal | 31 (11.40) | 11 (10.58) | |||
| Temporal | 22 (8.09) | 9 (8.65) | |||
| Occipital | 26 (9.56) | 29 (27.88) | |||
| Basal ganglia | 84 (30.88) | 20 (19.23) | |||
| Posterior fossa | 51 (18.75) | 5 (4.81) | |||
| Others | 3 (1.10) | 16 (8-27) | |||
| Hospital stay(d), median (IQR） | 15 (7-23) | 9 (7-12) | 0.261 | ||
| Basline NIHSS score, median(IQR) | 8 (6-11) | 26 (22-28) | 〈0.001 | ||
| Basline MMSE score, median(IQR) | 28 (25-30) | 2 (1-4) | 0.024 | ||
| mRS at 3 months, median (IQR） | 2 (1-2) | 3.81 (2.52-4.67) | 0.072 | ||
| NLR, median (IQR) | 2.83 (2.31-3.79) | 159.74 (124.87, 246.05) | 1.96 (1.54-2.57) | < 0.001 | < 0.001 |
| PLR, median (IQR) | 112.04 (89.25, 143.73) | 41.20 (29.53-50.32) | 112.17 (87.36, 142.3) | < 0.001 | < 0.001 |
| IL-17 (pg/mL), median (IQR) | 17.35 (10.13-19.79) | 32.47 (21.72-39.12) | 0.012 | ||
| IL-6 (pg/mL), median (IQR) | 15.85 (18.34-21.16) | 0.008 | |||