2.

Linc00261与患者无瘤生存时间的单因素和多因素COX回归分析

Univariate and multivariate Cox regression analyses of linc00261 for predicting recurrence-free survival of the patients (n=74)

Variables	HR	95%CI	P
a: Portal vein tumor thrombosis; b: Micro-vascular invasion.
Univariate analysis
Age (＜60 vs＞60 years)	1.433	0.721-2.847	0.305
Gender (male vs female)	0.744	0.335-1.653	0.468
AFP (＜400 vs ≥400)	1.181	0.706-1.974	0.526
Liver cirrhosis(Yes vs No)	1.259	0.667-2.377	0.477
Capsule(Yes vs No)	0.897	0.509-1.580	0.706
Tumor size (＜3 vs ≥3 cm)	3.913	1.564-9.794	0.004
Tumor number	2.155	1.176-3.984	0.013
MVIa (Yes vs No)	3.075	1.778-5.320	0.000
PVTTb (Yes vs No)	3.510	1.983-6.211	0.000
Differentiation (well, moderate, poor)	0.472	0.306-0.728	0.001
Expression of Linc00261 (high vs low)	0.215	0.098-0.475	0.000
Multivariate analysis
Tumor size (＜3 vs ≥3 cm)	3.293	0.745-14.561	0.116
Tumor number	4.335	1.591-11.813	0.004
MVI(Yes vs No)	3.662	1.422-9.431	0.007
PVTT(Yes vs No)	3.762	1.549-9.136	0.003
Differentiation (well, moderate, poor)	0.549	0.304-0.991	0.047
Linc00261 expression (high vs low)	0.294	0.127-0.683	0.004