Table 3: Bone Structure.
Includes data only from those biopsied in the untreated state.
| CONTROL N=40 | ALL IOP N=54 | p* All IOP vs Controls | AMONG ALL IOP |
p* PLO vs Control | |||
|---|---|---|---|---|---|---|---|
| PLO N=7 | IOP (non-PLO) N=47 | p* PLO vs IOP | |||||
| Trabecular Structure based on 3D MicroCT | |||||||
| BV/TV (%) | 23.7 ± 7.7 | 19.9 ± 6.3 | 0.01 | 21.8 ± 8.2 | 19.7 ± 6.1 | 0.4 | 0.6 |
| Tb Thickness (µm) | 161 ± 38 | 166 ± 42 | 0.6 | 178 ± 61 | 164 ± 39 | 0.4 | 0.3 |
| Tb Number (1/mm) | 1.8 ± 0.4 | 1.5 ± 0.2 | <0.0001 | 1.5 ± 0.2 | 1.5 ± 0.2 | 0.8 | 0.02 |
| Tb Separation (µm) | 625 ± 61 | 703 ± 75 | <0.0001 | 697 ± 75 | 703 ± 76 | 0.8 | 0.008 |
| Trabecular Structure based on 2D Histomorphometry | |||||||
| BV/TV (%) | 21.6 ± 5.4 | 18.1 ± 4.5 | 0.001 | 17.5 ± 3.1 | 18.2 ± 4.7 | 0.7 | 0.06 |
| Tb Width (µm) | 133 ± 24 | 117 ± 27 | 0.004 | 123 ± 37 | 116 ± 25 | 0.5 | 0.4 |
| Tb Number (#/mm2) | 1.6 ± 0.3 | 1.6 ± 0.3 | 0.5 | 1.5 ± 0.3 | 1.6 ± 0.3 | 0.4 | 0.2 |
| Tb Separation (µm) | 621 ± 109 | 657 ± 171 | 0.2 | 693 ± 169 | 652 ± 172 | 0.6 | 0.1 |
| Cortical Structure based on Histomorphometry | |||||||
| Cortical Width (µm) | 866 ± 212 | 671 ± 232 | <0.001 | 547 ± 219 | 689 ± 230 | 0.1 | <0.001 |
| Cortical Pore Area (%) | 7.4 ± 3.1 | 5.8 ± 3.1 | 0.3 | 6.3 ± 3.9 | 5.8 ± 2.9 | 0.7 | 0.4 |
| Pore #/Cortical Area (#/mm2) | 5.4 ± 1.7 | 5.8 ± 2.3 | 0.07 | 5.7 ± 1.2 | 5.8 ± 2.4 | 0.9 | 0.6 |
| Cells/Cancellous Bone Surface | |||||||
| Osteoblast Number (#/mm) | 1.03 ± 0.57 | 1.38 ± 0.97 | 0.03 | 1.85 ± 1.27 | 1.31 ± 0.91 | 0.2 | 0.1 |
| Osteoclast Number (#/mm) | 0.03 ± 0.02 | 0.05 ± 0.04 | 0.02 | 0.04 ± 0.03 | 0.05 ± 0.04 | 0.8 | 0.2 |
*
Two sample t-tests used for comparisons between groups.